UW Biostatistics Working Paper Series

Papers from 2008
Nonparametric Heteroscedastic Transformation Regression Models for Skewed Data with an Application to Health Care Costs (April 30, 2008) Xiao-Hua Zhou, Huazhen Lin, and Eric Johnson
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Semiparametric Inferential Procedures for Comparing Multivariate ROC Curves with Interaction Terms (April 29, 2008) Liansheng Tang and Xiao-Hua Zhou
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Semi-Parametric Maximum Likelihood Estimates for ROC Curves of Continuous-Scale Tests (April 25, 2008) Xiao-Hua Zhou and Huazhen Lin
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Multiple imputation of timing of mother-to-child transmission of HIV (February 25, 2008) Elizabeth Brown and Ying Qing Chen
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Estimation and Comparison of Receiver Operating Characteristic Curves (January 22, 2008) Margaret Pepe, Gary M. Longton, and Holly Janes
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Accommodating Covariates in ROC Analysis (January 22, 2008) Holly Janes, Gary M. Longton, and Margaret Pepe
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Papers from 2007
Model-Robust Bayesian Regression and the Sandwich Estimator (December 26, 2007) Adam A. Szpiro, Kenneth M. Rice, and Thomas Lumley
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Estimating Sensitivity and Specificity from a Phase 2 Biomarker Study that Allows for Early Termination (December 12, 2007) Margaret S. Pepe PhD
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Longitudinal Data with Follow-up Truncated by Death: Finding a Match Between Analysis Method and Research Aims (November 27, 2007) Brenda Kurland, Laura Lee Johnson, and Paula Diehr
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A Parametric ROC Model Based Approach for Evaluating the Predictiveness of Continuous Markers in Case-control Studies (November 14, 2007) Ying Huang and Margaret Pepe
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Identifiability and Estimation of Causal Effects in Randomized Trials with Noncompliance and Completely Non-ignorable Missing-Data (November 1, 2007) Hua Chen, Zhi Geng, and Xiao-Hua Zhou
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Nonparametric and Semiparametric Group Sequential Methods for Comparing Accuracy of Diagnostic Tests (October 22, 2007) Liansheng Tang, Scott S. Emerson, and Xiao-Hua Zhou
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ROC Surfaces in the Presence of Verification Bias (September 7, 2007) Yueh-Yun Chi and Xiao-Hua (Andrew) Zhou
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A Censored Multinomial Regression Model for Perinatal Mother to Child Transmission of HIV (July 25, 2007) Charlotte C. Gard and Elizabeth R. Brown
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Reporting and Interpretation in Genome-Wide Association Studies (July 11, 2007) Jon Wakefield
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Evaluating the ROC Performance of Markers for Future Events (May 11, 2007) Margaret Pepe, Yingye Zheng, and Yuying Jin
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Adjusting for Covariates in Studies of Diagnostic, Screening, or Prognostic Markers: An Old Concept in a New Setting (May 7, 2007) Holly Janes and Margaret Pepe
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Gamma Generalized Linear Models for Pharmacokinetic Data (May 2, 2007) Ruth Salway and Jon Wakefield
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Ecologic Studies Revisited (May 2, 2007) Jon Wakefield
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Evaluating a Group Sequential Design in the Setting of Nonproportional Hazards (May 1, 2007) Daniel L. Gillen and Scott S. Emerson
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Biomarker Evaluation Using the Controls as a Reference Population (April 27, 2007) Ying Huang and Margaret Pepe
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What Is the Best Reference RNA? And Other Questions Regarding the Design and Analysis of Two-Color Microarray Experiments (April 10, 2007) Kathleen F. Kerr, Kyle A. Serikawa, Caimiao Wei, Mette A. Peters, and Roger E. Bumgarner
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Multiple Imputation Methods for Treatment Noncompliance and Missing Data (March 1, 2007) Leslie Taylor and Xiao-Hua (Andrew) Zhou
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Power Boosting in Genome-Wide Studies Via Methods for Multivariate Outcomes (February 20, 2007) Mary J. Emond
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Papers from 2006
A Semiparametric Approach for the Nonparametric Transformation Survival Model With Multiple Covariates (December 7, 2006) Xiao Song, Shuangge Ma, Jian Huang, and Xiao-Hua Zhou
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Large Cluster Asymptotics for GEE: Working Correlation Models (October 26, 2006) Hyoju Chung and Thomas Lumley
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Statistical Analysis of Air Pollution Panel Studies: An Illustration (October 19, 2006) Holly Janes, Lianne Sheppard, and Kristen Shepherd
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On the Structure of Multiple Testing Procedures (September 19, 2006) Jeffrey Leek and John D. Storey
Summary
COVARIATE SPECIFIC ROC CURVE WITH SURVIVAL OUTCOME (September 18, 2006) Xiao Song and Xiao-Hua Zhou
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Assessing the Adequacy of Variance Function in Heteroscedastic Regression Models (September 7, 2006) Lan Wang and Xiao-Hua Andrew Zhou
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Multiple imputation for the comparison of two screening tests in two-phase Alzheimer studies (September 7, 2006) Ofer Harel and Xiao-Hua Zhou
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Multiple imputation - Review of theory, implementation and software (September 7, 2006) Ofer Harel and Xiao-Hua Zhou
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Generalized confidence intervals for the ratio or difference of two means for lognormal populations with zeros (September 7, 2006) Yea-Hung Chen and Xiao-Hua Zhou
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Relative Risk Regression in Medical Research: Models, Contrasts, Estimators, and Algorithms (July 19, 2006) Thomas Lumley, Richard Kronmal, and Shuangge Ma
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The Combination of Ecological and Case-Control Data (July 12, 2006) Sebastien Haneuse and Jon Wakefield
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Evaluating Causal Effect Predictiveness of Candidate Surrogate Endpoints (July 6, 2006) Peter B. Gilbert and Michael Hudgens
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Hierarchical Lévy Frailty Models and a Frailty Analysis of Data on Infant Mortality in Norwegian Siblings (June 19, 2006) Tron Anders Moger and Odd O. Aalen
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Integrating the Predictiveness of a Marker with its Performance as a Classifier (June 1, 2006) Margaret S. Pepe, Ziding Feng, Ying Huang, Gary M. Longton, Ross Prentice, Ian M. Thompson, and Yingye Zheng
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A Marginalized Diffusion Model for Estimating Age at First Endoscopy Examination from Current Status Data (May 26, 2006) Diana Miglioretti and Elizabeth Brown
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Hierarchical Models for Combining Ecological and Case-control Data (May 22, 2006) Sebastien Haneuse and Jon Wakefield
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Disease Mapping and Spatial Regression with Count Data (May 8, 2006) Jon Wakefield
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Functional ANOVA Normalization of Two-Channel Microarrays (April 18, 2006) Alan Dabney and John D. Storey
Summary
Reliability, Effect Size, and Responsiveness and Intraclass Correlation of Health Status Measures Used in Randomized and Cluster-Randomized Trials (March 24, 2006) Paula Diehr, Lu Chen, Donald L. Patrick, Ziding Feng, and Yutaka Yasui
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Adjusting for Covariate Effects on Classification Accuracy Using the Covariate-Adjusted ROC Curve (March 17, 2006) Holly Janes and Margaret S. Pepe
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Genome Scanning Methods for Comparing Sequences Between Groups, with Application to HIV Vaccine Trials (March 15, 2006) Peter B. Gilbert, Chunyuan Wu, and David V. Jobes
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The Two-sample Problem for Failure Rates Depending on a Continuous Mark: An Application to Vaccine Efficacy (March 15, 2006) Peter B. Gilbert, Ian W. McKeague, and Yanqing Sun
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2^k Factorials in Blocks of Size 2, with Application to Two-Color Microarray Experiments (March 2, 2006) Kathleen F. Kerr
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Evaluating the Predictiveness of a Continuous Marker (March 1, 2006) Ying Huang, Margaret S. Pepe, and Ziding Feng
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Different Public Health Interventions have Varying Effects (February 21, 2006) Paula Diehr, Anne B. Newman, Liming Cai, and Ann Derleth
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Comparison of Haplotype-based and Tree-based SNP Imputation in Association Studies (January 13, 2006) James Y. Dai, Ingo Ruczinski, Michael LeBlanc, and Charles Kooperberg
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Case-cohort Methods for Survival Data on Families from Routine Registers (January 13, 2006) Tron Anders Moger, Yudi Pawitan, and Ørnulf Borgan
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Papers from 2005
Semiparametric Approaches for Joint modeling of Longitudinal and Survival Data with Time Varying Coefficients (December 30, 2005) Xiao Song and C.Y. Wang
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Bayesian Analysis of Cell-Cycle Gene Expression Data (December 21, 2005) Chuan Zhou, Jon Wakefield, and Linda Breeden
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Alleviating Linear Ecological Bias and Optimal Design with Subsample Data (December 21, 2005) Adam Glynn, Jon Wakefield, Mark Handcock, and Thomas Richardson
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A Hybrid Model for Reducing Ecological Bias (December 20, 2005) Ruth Salway and Jon Wakefield
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Health-Exposure Modelling and the Ecological Fallacy (December 15, 2005) Jon Wakefield and Gavin Shaddick
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Confidence Intervals for Predictive Values Using Data from a Case Control Study (December 7, 2005) Nathaniel David Mercaldo, Xiao-Hua Zhou, and Kit F. Lau
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Inferences in Censored Cost Regression Models with Empirical Likelihood (December 7, 2005) Xiao-Hua Zhou, Gengsheng Qin, Huazhen Lin, and Gang Li
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Interval Estimation for the Ratio and Difference of Two Lognormal Means (December 7, 2005) Yea-Hung Chen and Xiao-Hua Zhou
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Empirical Likelihood Inference for the Area Under the ROC Curve (December 7, 2005) Gengsheng Qin and Xiao-Hua Zhou
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Optimal Feature Selection for Nearest Centroid Classifiers, With Applications to Gene Expression Microarrays (November 28, 2005) Alan R. Dabney and John D. Storey
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A New Approach to Intensity-Dependent Normalization of Two-Channel Microarrays (November 28, 2005) Alan R. Dabney and John D. Storey
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Estimating a Treatment Effect with Repeated Measurements Accounting for Varying Effectiveness Duration (November 13, 2005) Ying Qing Chen, Jingrong Yang, and Su-Chun Cheng
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Is the Number of Sick Persons in a Cohort Constant Over Time? (October 1, 2005) Paula Diehr, Ann Derleth, Anne Newman, and Liming Cai
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Semiparametric Loglinear Regression for Longitudinal Measurements Subject to Irregular, Biased Follow-up (September 26, 2005) Petra Buzkova and Thomas Lumley
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Longitudinal Data Analysis for Generalized Linear Models under Irregular, Biased Sampling: Situations with Follow-up Dependent on Outcome or Auxiliary Outcome-related Variables (September 26, 2005) Petra Buzkova and Thomas Lumley
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Marginal Regression Modeling under Irregular, Biased Sampling (September 26, 2005) Petra Buzkova and Thomas Lumley
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The Optimal Discovery Procedure: A New Approach to Simultaneous Significance Testing (September 6, 2005) John D. Storey
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The Optimal Discovery Procedure for Large-Scale Significance Testing, with Applications to Comparative Microarray Experiments (September 1, 2005) John D. Storey, James Y. Dai, and Jeffrey T. Leek
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Linear Regression of Censored Length-biased Lifetimes (July 18, 2005) Ying Qing Chen and Yan Wang
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Sensitivity Analysis in Randomized Clinical Trials with Missing Data and Non-compliance (July 7, 2005) L Taylor and Xiao-Hua Zhou
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On Additive Regression of Expectancy (June 28, 2005) Ying Qing Chen
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An Empirical Process Limit Theorem for Sparsely Correlated Data (June 9, 2005) Thomas Lumley
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Attributable Risk Function in the Proportional Hazards Model (May 31, 2005) Ying Qing Chen, Chengcheng Hu, and Yan Wang
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A Linear Regression Framework for Receiver Operating Characteristic(ROC) Curve Analysis (May 31, 2005) Zheng Zhang and Margaret S. Pepe
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Multiple Imputation for Correcting Verification Bias (May 11, 2005) Ofer Harel and Xiao-Hua Zhou
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A Comparison of Parametric and Coarsened Bayesian Interval Estimation in the Presence of a Known Mean-Variance Relationship (April 28, 2005) Kent Koprowicz, Scott S. Emerson, and Peter Hoff
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Application of the Time-Dependent ROC Curves for Prognostic Accuracy with Multiple Biomarkers (April 8, 2005) Yingye Zheng, Tianxi Cai, and Ziding Feng
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Semi-Parametric Maximum Likelihood Estimates for ROC Curves of Continuous-Scale Tests (March 30, 2005) Xiao-Hua Zhou and Hua Zhen Lin
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Nonparametric Statistical Methods for the Cost-Effectiveness Analysis (March 30, 2005) Phillip Dinh and Xiao-Hua Zhou
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Empirical Likelihood Intervals for the Mean Difference of Two Skewed Populations with Additional Zero Values (March 30, 2005) W. Zhou and Xiao-Hua Zhou
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ITT Analysis of Randomized Encouragement Design Studies with Missing-Data (March 30, 2005) Xiao-Hua Zhou, Richard Wang, and Sierra M. Li
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Constructing Confidence Intervals of the Summary Statistics in the Least-Squares SROC Model (March 28, 2005) Ming-Yu Fan and Xiao-Hua Zhou
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New Confidence Intervals for the Difference between Two Sensitivities at a Fixed Level of Specificity (March 14, 2005) Gengsheng Qin, Yu-Sheng Hsu, and Xiao-Hua Zhou
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On the Use of Stochastic Curtailment in Group Sequential Clinical Trials (March 9, 2005) Scott S. Emerson, John M. Kittelson, and Daniel L. Gillen
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Bayesian Evaluation of Group Sequential Clinical Trial Designs (March 9, 2005) Scott S. Emerson, John M. Kittelson, and Daniel L. Gillen
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Frequentist Evaluation of Group Sequential Clinical Trial Designs (March 9, 2005) Scott S. Emerson, John M. Kittelson, and Daniel L. Gillen
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The Clustering of Regression Models Method with Applications in Gene Expression Data (January 25, 2005) Li-Xuan Qin and Steven G. Self
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Combining Predictors for Classification using the Area Under the ROC Curve (January 7, 2005) Margaret S. Pepe, Tianxi Cai, Zheng Zhang, and Gary M. Longton
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Standardizing Markers to Evaluate and Compare their Performances (January 7, 2005) Margaret S. Pepe and Gary M. Longton
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Insights into Latent Class Analysis (January 7, 2005) Margaret S. Pepe and Holly Janes
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Limitations of the Odds Ratio in Gauging the Performance of a Diagnostic or Prognostic Marker (January 7, 2005) Margaret S. Pepe, Holly Janes, Gary M. Longton, Wendy Leisenring, and Polly Newcomb
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Papers from 2004
Referent Selection Strategies in Case-Crossover Analyses of Air Pollution Exposure Data: Implications for Bias (December 13, 2004) Holly Janes, Lianne Sheppard, and Thomas Lumley
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Semi-parametric Single-index Two-Part Regression Models (December 6, 2004) Xiao-Hua Zhou and Hua Liang
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Estimating the Retransformed Mean in a Heteroscedastic Two-Part Model (September 29, 2004) Alan H. Welsh and Xiao-Hua Zhou
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A Marginal Model Approach for Analysis of Multi-reader Multi-test Receiver Operating Characteristic (ROC) Data (September 16, 2004) Xiao Song and Xiao-Hua Zhou
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Nonparametric Confidence Intervals for the One- and Two-Sample Problems (September 14, 2004) Xiao-Hua Zhou and Phillip Dinh
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Significance Analysis of Time Course Microarray Experiments (August 31, 2004) John D. Storey, Wenzhong Xiao, Jeffrey T. Leek, Ronald G. Tompkins, and Ron W. Davis
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Non-Parametric Estimation of ROC Curves in the Absence of a Gold Standard (July 30, 2004) Xiao-Hua Zhou, Pete Castelluccio, and Chuan Zhou
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Combining Predictors for Classification Using the Area Under the ROC Curve (June 7, 2004) Margaret S. Pepe, Tianxi Cai, and Zheng Zhang
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Quantifying and Comparing the Accuracy of Binary Biomarkers When Predicting a Failure Time Outcome (May 12, 2004) Chaya S. Moskowitz and Margaret S. Pepe
Summary
On Corrected Score Approach for Proportional Hazards Model with Covariate Measurement Error (May 6, 2004) Xiao Song and Yijian Huang
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Evaluating Markers for Selecting a Patient's Treatment (April 8, 2004) Xiao Song and Margaret S. Pepe
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Incorporating Death into Health-Related Variables in Longitudinal Studies (January 29, 2004) Paula Diehr, Laura Lee Johnson, Donald L. Patrick, and Bruce Psaty
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Calibrating Observed Differential Gene Expression for the Multiplicity of Genes on the Array (January 29, 2004) Yingye Zheng and Margaret S. Pepe
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Overlap Bias in the Case-Crossover Design, With Application to Air Pollution Exposures (January 13, 2004) Holly Janes, Lianne Sheppard, and Thomas Lumley
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Papers from 2003
Marginalized Transition Models for Longitudinal Binary Data With Ignorable and Nonignorable Dropout (December 22, 2003) Brenda F. Kurland and Patrick J. Heagerty
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Partly Conditional Survival Models for Longitudinal Data (December 19, 2003) Yingye Zheng and Patrick Heagerty
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Semiparametric Estimation of Time-Dependent: ROC Curves for Longitudinal Marker Data (December 19, 2003) Yingye Zheng and Patrick Heagerty
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Survival Model Predictive Accuracy and ROC Curves (December 19, 2003) Patrick Heagerty and Yingye Zheng
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Marginal Modeling of Multilevel Binary Data with Time-Varying Covariates (December 19, 2003) Diana Miglioretti and Patrick Heagerty
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A Corrected Pseudo-score Approach for Additive Hazards Model With Longitudinal Covariates Measured With Error (November 13, 2003) Xiao Song and Yijian Huang
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Adjusting for Non-Ignorable Verification Bias in Clinical Studies for Alzheimer’s Disease (July 11, 2003) Xiao-Hua Zhou and Pete Castelluccio
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Design Considerations for Efficient and Effective Microarray Studies (June 13, 2003) M. Kathleen Kerr
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Tests for Comparing Mark-Specific Hazards and Cumulative Incidence Functions (June 13, 2003) Peter B. Gilbert, Ian W. McKeague, and Yanqing Sun
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Sensitivity Analysis for the Assessment of Causal Vaccine Effects on Viral Load in HIV Vaccine Trials (June 13, 2003) Peter B. Gilbert, Ronald J. Bosch, and Michael G. Hudgens
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Asymptotics for Marginal Generalized Linear Models With Sparse Correlations (June 11, 2003) Thomas Lumley and Nicole Mayer Hamblett
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A New Confidence Interval for the Difference Between Two Binomial Proportions of Paired Data (June 2, 2003) Xiao-Hua Zhou and Gengsheng Qin
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Identifying Target Populations for Screening or Not Screening Using Logic Regression (May 23, 2003) Holly Janes, Margaret S. Pepe, Charles Kooperberg, and Polly Newcomb
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Improved Confidence Intervals for the Sensitivity at a Fixed Level of Specificity of a Continuous-Scale Diagnostic Test (May 21, 2003) Xiao-Hua Zhou and Gengsheng Qin
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Bootstrap Confidence Intervals for Medical Costs With Censored Observations (May 20, 2003) Hongyu Jiang and Xiao-Hua Zhou
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New Intervals for the Difference Between Two Independent Binomial Proportions (May 19, 2003) Xiao-Hua Zhou, Min Tsao, and Gengsheng Qin
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Linear Models for Microarray Data Analysis: Hidden Similarities and Differences (May 16, 2003) M. Kathleen Kerr
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A Bootstrap Confidence Interval Procedure for the Treatment Effect Using Propensity Score Subclassification (May 15, 2003) Wanzhu Tu and Xiao-Hua Zhou
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Constrained Boundary Monitoring for Group Sequential Clinical Trials (April 25, 2003) Bart E. Burington and Scott S. Emerson
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Estimating the accuracy of polymerase chain reaction-based tests using endpoint dilution (March 20, 2003) Jim Hughes and Patricia Totten
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Design of the HIV Prevention Trials Network (HPTN) Protocol 054: A cluster randomized crossover trial to evaluate combined access to Nevirapine in developing countries (March 18, 2003) Jim Hughes, Robert L. Goldenberg, Catherine M. Wilfert, Megan Valentine, Kasonde G. Mwinga, Laura A. Guay, Francis Mmiro, and Jeffrey S. A. Stringer
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Literate Statistical Practice (March 5, 2003) Anthony Rossini and Friedrich Leisch
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Simple Parallel Statistical Computing in R (March 5, 2003) Anthony Rossini, Luke Tierney, and Na Li
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The Sensitivity and Specificity of Markers for Event Times (January 27, 2003) Tianxi Cai, Margaret S. Pepe, Thomas Lumley, Yingye Zheng, and Nancy Swords Jenny
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Semi-parametric Regression for the Area Under the Receiver Operating Characteristic Curve (January 27, 2003) Lori E. Dodd and Margaret S. Pepe
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Semiparametric Receiver Operating Characteristic Analysis to Evaluate Biomarkers for Disease (January 27, 2003) Tianxi Cai and Margaret S. Pepe
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Selecting Differentially Expressed Genes from Microarray Experiments (January 27, 2003) Margaret S. Pepe, Gary M. Longton, Garnet L. Anderson, and Michel Schummer
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Whither PQL? (January 24, 2003) Norm Breslow
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Estimating Disease Prevalence in Two-Phase Studies (January 24, 2003) Todd A. Alonzo and Margaret S. Pepe
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Partial AUC Estimation and Regression (January 13, 2003) Lori E. Dodd and Margaret S. Pepe
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Modeling Breastmilk Infectivity in HIV-1 Infected Mothers (January 2, 2003) Barbra A. Richardson and James P. Hughes
Summary
Papers from 2002
The Analysis of Placement Values for Evaluating Discriminatory Measures (September 30, 2002) Margaret S. Pepe and Tianxi Cai
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Large Sample Theory for Semiparametric Regression Models with Two-Phase, Outcome Dependent Sampling (February 22, 2002) Norm Breslow, Brad McNeney, and Jon A. Wellner
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A Data-Analytic Strategy for Protein-Biomarker Discovery: Profiling of High-Dimensional Proteomic Data for Cancer Detection (January 31, 2002) Yutaka Yasui, Margaret S. Pepe, Mary Lou Thompson, Bao-Ling Adam, George L. Wright Jr., Yinsheng Qu, John D. Potter, Marcy Winget, Mark Thornquist, and Ziding Feng
Summary
Performance of the Halex in Logitudinal Studies of Older Adults (January 25, 2002) Paula Diehr, Donald L. Patrick, Gregory L. Burke, and Jeff D. Williamson
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Papers from 2001
Emacs Speaks Statistics: A Universal Interface for Statistical Analysis (July 17, 2001) Anthony Rossini, Martin Maechler, Kurt Hornik, Richard M. Heiberger, and Rodney Sparapani
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Probabilities of Transition Among Health States for Older Adults (January 1, 2001) Paula Diehr and Donald L. Patrick
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Papers from 1998
Selection of Matching Variables in Community Health Intervention Trials (December 15, 1998) Andrew J. Dunning
Summary
Assessing the Accuracy of a New Diagnostic Test When a Gold Standard Does Not Exist (October 1, 1998) Todd A. Alonzo and Margaret S. Pepe
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Papers from 1997
Multiple Outcomes in Health Services Research: Hypothesis Tests and Power (October 1, 1997) Donald C. Martin, Paula Diehr, Thomas D. Koepsell, and Stephan D. Fihn
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Pooling Community Data for Community Interventions When the Number of Pairs is Small (May 20, 1997) Paula Diehr, Ted Lystig, Holly Andrilla, and Ziding Feng
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Papers from 1995
Breaking the Matches in a Paired T-Test for Community Interventions When the Number of Pairs is Small (July 1, 1995) Paula Diehr, Don C. Martin, Thomas D. Koepsell, and Allen D. Cheadle
Summary
Papers from 1994
An Empirical Study of Small-Area Variation for ICD-9 Surgical Procedures (April 30, 1994) Paula Diehr, Kevin Cain, Zhan Ye, and John Loeser
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Papers from 1992
The Multiple Admission Factor (MAF) in Small Area Variation Analysis (December 1, 1992) Kevin Cain and Paula Diehr
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Papers from 1989
Regression Models for Bivariate Binary Responses (November 1, 1989) Juni Palmgren
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Papers from 1980
Sample Size Calculations and Optimal Followup Time in Health Services Research Using Utilization Rates (August 22, 1980) Paula Diehr
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Papers from 1978
Statistical Measures for Admission Rates (August 18, 1978) Paula Diehr
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