Harvard University Biostatistics Working Paper Series

Papers from 2008
Semiparametric Maximum Likelihood Estimation in Normal Transformation Models for Bivariate Survival Data (June 20, 2008) Yi Li, Ross L. Prentice, and Xihong Lin
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A Comparison of Methods for Estimating the Causal Effect of a Treatment in Randomized Clinical Trials Subject to Noncompliance (June 20, 2008) Rod Little, Qi Long, and Xihong Lin
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Nonparametric Regression Using Local Kernel Estimating Equations for Correlated Failure Time Data (June 20, 2008) Zhangsheng Yu and Xihong Lin
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A Powerful and Flexible Multilocus Association Test for Quantitative Traits (June 20, 2008) Lydia Coulter Kwee, Dawei Liu, Xihong Lin, Debashis Ghosh, and Michael P. Epstein
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Estimation and Testing for the Effect of a Genetic Pathway on a Disease Outcome Using Logistic Kernel Machine Regression via Logistic Mixed Models (June 20, 2008) Dawei Liu, Debashis Ghosh, and Xihong Lin
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Model-based Clustering of Methylation Array Data: A Recursive-partitioning Algorithm for High-dimensional Data Arising as a Mixture of Beta Distributions (June 5, 2008) E. Andres Houseman, Brock C. Christensen, Ru-Fang Yeh, Carmen J. Marsit, Margaret R. Karagas, Margaret Wrensch, Heather H. Nelson, Joseph Wiemels, Shichun Zheng, John K. Wiencke, and Karl T. Kelsey
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Matrix Pooling: An Accurate and Cost Effective Testing Algorithm for Detection of Acute HIV Infection (April 28, 2008) Bethany L. Hedt and Marcello Pagano
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A Matrix Pooling Algorithm for Disease Detection (April 24, 2008) Bethany L. Hedt and Marcello Pagano
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Nonparametric Inference Procedure For Percentiles of the Random Effect Distribution in Meta Analysis (April 10, 2008) Rui Wang, Lu Tian, Tianxi Cai, and L. J. Wei
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Marginal Structural Models for Partial Exposure Regimes (February 25, 2008) Stijn Vansteelandt, Karl Mertens, Carl Suetens, and Els Goetghebeur
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Empirical Null and False Discovery Rate Inference for Exponential Families (February 25, 2008) Armin Schwartzman
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Practical Large-Scale Spatio-Temporal Modeling of Particulate Matter Concentrations (January 15, 2008) Christopher J. Paciorek, Jeff D. Yanosky, and Helen H. Suh
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Estimation of Controlled Direct Effects (January 11, 2008) Sylvie Goetgeluk, Stijn Vansteelandt, and Els Goetghebeur
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Papers from 2007
Spatio-temporal Associations Between GOES Aerosol Optical Depth Retrievals and Ground-Level PM2.5 (December 19, 2007) Christopher J. Paciorek, Yang Liu, Hortensia Moreno-Macias, and Shobha Kondragunta
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Assessing Population Level Genetic Instability via Moving Average (November 6, 2007) Samuel McDaniel, Rebecca Betensky, and Tianxi Cai
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Mapping Ancient Forests: Bayesian Inference for Spatio-temporal Trends in Forest Composition Using the Fossil Pollen Proxy Record (September 4, 2007) Christopher J. Paciorek and Jason S. McLachlan
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Comparing Trends in Cancer Rates Across Overlapping Regions (August 27, 2007) Yi Li and Ram C. Tiwari
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Correcting Instrumental Variables Estimators for Systematic Measurement Error (August 21, 2007) Stijn Vansteelandt, Manoochehr Babanezhad, and Els Goetghebeur
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Effectively Combining Independent 2 x 2 Tables for Valid Inferences in Meta Analysis with all Available Data but no Artificial Continuity Corrections for Studies with Zero Events and its Application to the Analysis of Rosiglitazone's Cardiovascular Disease Related Event Data (August 13, 2007) Lu Tian, Tianxi Cai, Nikita Piankov, Pierre-Yves Cremieux, and L. J. Wei
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Survival Analysis with Large Dimensional Covariates: An Application in Microarray Studies (July 10, 2007) David A. Engler and Yi Li
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Assessment of a CGH-based Genetic Instability (July 10, 2007) David A. Engler, Yiping Shen, J F. Gusella, and Rebecca A. Betensky
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Simultaneous Confidence Intervals Based on the Percentile Bootstrap Approach (June 28, 2007) Micha Mandel and Rebecca A. Betensky
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Estimating Time-to-Event From Longitudinal Categorical Data Using Random Effects Markov Models: Application to Multiple Sclerosis Progression (June 28, 2007) Micha Mandel and Rebecca A. Betensky
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Identifying patients who need additional biomarkers for better prediction of health outcome or diagnosis of clinical phenotype (June 19, 2007) Lu Tian, Tianxi Cai, and L. J. Wei
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Conservative Estimation of Optimal Multiple Testing Procedures (March 20, 2007) James E. Signorovitch
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Papers from 2006
A Likelihood Based Method for Real Time Estimation of the Serial Interval and Reproductive Number of an Epidemic (December 20, 2006) Laura Forsberg White and Marcello Pagano
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Semiparametric Regression of Multi-Dimensional Genetic Pathway Data: Least Squares Kernel Machines and Linear Mixed Models (November 28, 2006) Dawei Liu, Xihong Lin, and Debashis Ghosh
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Spatio-Temporal Analysis of Areal Data and Discovery of Neighborhood Relationships in Conditionally Autoregressive Models (November 28, 2006) Subharup Guha and Louise Ryan
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Multiple Testing With an Empirical Alternative Hypothesis (November 7, 2006) James E. Signorovitch
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Measurement Error Caused by Spatial Misalignment in Environmental Epidemiology (November 2, 2006) Alexandros Gryparis, Christopher J. Paciorek, Ariana Zeka, Joel Schwartz, and Brent A. Coull
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Bayesian Hidden Markov Modeling of Array CGH Data (October 13, 2006) Subharup Guha, Yi Li, and Donna Neuberg
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Spatial Cluster Detection for Censored Outcome Data (September 13, 2006) Andrea J. Cook, Diane Gold, and Yi Li
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A Comparison of Methods for Estimating the Causal Effect of a Treatment in Randomized Clinical Trials Subject to Noncompliance (August 30, 2006) Rod Little, Qi Long, and Xihong Lin
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Causal Inference in Hybrid Intervention Trials Involving Treatment Choice (August 30, 2006) Qi Long, Rod Little, and Xihong Lin
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Nonparametric Regression Using Local Kernel Estimating Equations for Correlated Failure Time Data (August 30, 2006) Zhangsheng Yu and Xihong Lin
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Estimation in Semiparametric Transition Measurement Error Models for Longitudinal Data (August 30, 2006) Wenqin Pan, Donglin Zeng, and Xihong Lin
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Structural Inference in Transition Measurement Error Models for Longitudinal Data (August 30, 2006) Wenqin Pan, Xihong Lin, and Donglin Zeng
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Bayesian Smoothing of Irregularly-spaced Data Using Fourier Basis Functions (August 10, 2006) Christopher J. Paciorek
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Predicting Future Responses Based on Possibly Misspecified Working Models (August 9, 2006) Tianxi Cai, Lu Tian, Scott D. Solomon, and L.J. Wei
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Mixed Multiplicative Factor Analysis Model for Air Pollution Exposure Assessment (July 24, 2006) Margaret C. Nikolov, Brent A. Coull, Paul J. Catalano, and John J. Godleski
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An Informative Bayesian Structural Equation Model to Assess Source-Specific Health Effects of Air Pollution (July 24, 2006) Margaret C. Nikolov, Brent A. Coull, Paul J. Catalano, and John J. Godleski
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A Computationally Tractable Multivariate Random Effects Model for Clustered Binary Data (June 28, 2006) Brent A. Coull, E. Andres Houseman, and Rebecca A. Betensky
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PLASQ: A Generalized Linear Model-Based Procedure to Determine Allelic Dosage ini Cancer Cells from SNP Array Data (June 1, 2006) Thomas LaFramboise, David P. Harrington, and Barbara A. Weir
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Using Profile Likelihood for Semiparametric Model Selection with Application to Proportional Hazards Mixed Models (May 31, 2006) Ronghui Xu, Anthony Gamst, Michael Donohue, Florin Vaida, and David P. Harrington
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Posterior Simulation in the Generalized Linear Model with Semiparmetric Random Effects (May 25, 2006) Subharup Guha
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Semiparametric Latent Variable Regression Models for Spatio-temporal Modeling of Mobile Source Particles in the Greater Boston Area (April 25, 2006) Alexandros Gryparis, Brent A. Coull, Joel Schwartz, and Helen H. Suh
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Survival Analysis with Change Point Hazard Functions (April 5, 2006) Melody S. Goodman, Yi Li, and Ram C. Tiwari
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Selecting 'Significant' Differentially Expressed Genes from the Combined Perspective of the Null and the Alternative (April 1, 2006) Beatrijs Moerkerke and Els Goetghebeur
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Evaluating Prediction Rules for t-Year Survivors With Censored Regression Models (March 10, 2006) Hajime Uno, Tianxi Cai, Lu Tian, and L.J. Wei
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A Diagnostic Test for the Mixing Distribution in a Generalised Linear Mixed Model (March 1, 2006) Eric J. Tchetgen and Brent A. Coull
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Regression Analysis for the Partial Area Under the ROC Curve (February 6, 2006) Tianxi Cai and Lori E. Dodd
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Papers from 2005
Model Checking for ROC Regression Analysis (December 6, 2005) Tianxi Cai and Yingye Zheng
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Model Evaluation Based on the Distribution of Estimated Absolute Prediction Error (November 7, 2005) Lu Tian, Tianxi Cai, Els Goetghebeur, and L. J. Wei
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Gauss-Seidel Estimation of Generalized Linear Mixed Models with Application to Poisson Modeling of Spatially Varying Disease Rates (October 12, 2005) Subharup Guha and Louise Ryan
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Computational Techniques for Spatial Logistic Regression with Large Datasets (October 7, 2005) Christopher J. Paciorek and Louise Ryan
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Designed Extension of Survival Studies: Application to Clinical Trials with Unrecognized Heterogeneity (October 7, 2005) Yi Li, Mei-Chiung Shih, and Rebecca A. Betensky
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Feature-Specific Penalized Latent Class Analysis for Genomic Data (September 29, 2005) E. Andres Houseman, Brent A. Coull, and Rebecca A. Betensky
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A Pseudolikelihood Approach for Simultaneous Analysis of Array Comparative Genomic Hybridizations (aCGH) (September 23, 2005) David A. Engler, Gayatry Mohapatra, David N. Louis, and Rebecca Betensky
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A Nonstationary Negative Binomial Time Series with Time-Dependent Covariates: Enterococcus Counts in Boston Harbor (September 13, 2005) E. Andres Houseman, Brent Coull, and James P. Shine
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Simultaneous and Exact Interval Estimates for the Contrast of Two Groups Based on an Extremely High Dimensional Response Variable: Application to Mass Spec Data Analysis (September 9, 2005) Yuhyun Park, Sean R. Downing, Cheng Li Dr., William C. Hahn, Philip W. Kantoff, and L. J. Wei
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Semiparametric Estimation in General Repeated Measures Problems (September 6, 2005) Xihong Lin and Raymond J. Carroll
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Inference on Survival Data with Covariate Measurement Error - An Imputation-based Approach (September 1, 2005) Yi Li and Louise Ryan
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Semiparametric Normal Transformation Models for Spatially Correlated Survival Data (September 1, 2005) Yi Li and Xihong Lin
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Mixture Cure Survival Models with Dependent Censoring (September 1, 2005) Yi Li, Ram C. Tiwari, and Subharup Guha
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The Sensitivity and Specificity of Markers for Event Times (April 5, 2005) Tianxi Cai, Margaret S. Pepe, Thomas Lumley, Yingye Zheng, and Nancy Swords Jenny
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Implementation Of Estimating-Function Based Inference Procedures With MCMC Sampler (February 14, 2005) Lu Tian, Jun S. Liu, and L. J. Wei
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Robust Inferences For Covariate Effects On Survival Time With Censored Linear Regression Models (January 3, 2005) Larry Leon, Tianxi Cai, and L. J. Wei
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Papers from 2004
Cholesky Residuals for Assessing Normal Errors in a Linear Model with Correlated Outcomes: Technical Report (October 18, 2004) E. Andres Houseman, Louise Ryan, and Brent Coull
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A Functional-Based Distribution Diagnostic for a Linear Model with Correlated Outcomes: Technical Report (October 18, 2004) E. Andres Houseman, Brent Coull, and Louise Ryan
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A Robust Regression Model for a First-Order Autoregressive Time Series with Unequal Spacing: Technical Report (October 15, 2004) E. Andres Houseman
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Semiparametric Methods for Semi-competing Risks Problem with Censoring and Truncation (October 12, 2004) Hongyu Jiang, Jason Fine, and Richard J. Chappell
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On the Accelerated Failure Time Model for Current Status and Interval Censored Data (September 1, 2004) Lu Tian and Tianxi Cai
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The Optimal Confidence Region for a Random Parameter (July 22, 2004) Hajime Uno, Lu Tian, and L.J. Wei
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One- and Two-Sample Nonparametric Inference Procedures in the Presence of Dependent Censoring (April 13, 2004) Yuhyun Park, Lu Tian, and L. J. Wei
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Papers from 2003
Empirical and Kernel Estimation of Covariate Distribution Conditional on Survival Time (December 1, 2003) Xiaochun Li and Ronghui Xu
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Estimating Predictors for Long- Or Short-Term Survivors (November 20, 2003) Lu Tian, Wei Wang, and L. J. Wei
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Survival Analysis with Heterogeneous Covariate Measurement Error (November 12, 2003) Yi Li and Louise Ryan
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A Nonparametric Comparison of Conditional Distributions with Nonnegligible Cure Fractions (November 12, 2003) Yi Li and Jin Feng
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Statistical Inference for Infinite Dimensional Parameters Via Asymptotically Pivotal Estimating Functions (November 6, 2003) Meredith A. Goldwasser, Lu Tian, and L. J. Wei
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Semi-parametric Box-Cox Power Transformation Models for Censored Survival Observations (October 30, 2003) Tianxi Cai, Lu Tian, and L. J. Wei
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STATISTICAL INFERENCES BASED ON NON-SMOOTH ESTIMATING FUNCTIONS (October 27, 2003) Lu Tian, Jun S. Liu, Mary Zhao, and L. J. Wei
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On the Cox Model with Time-Varying Regression Coefficients (October 24, 2003) Lu Tian, David Zucker, and L. J. Wei
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The Effects of Misspecifying Cox's Regression Model on Randomized Treatment Group Comparisons (October 16, 2003) Greg DiRienzo
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Nonparametric Methods to predict HIV drug susceptibility phenotype from genotype (October 16, 2003) Greg DiRienzo
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Nonparametric Comparison of Two Survival-Time Distributions in the Presence of Dependent Censoring (September 10, 2003) Greg DiRienzo
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