- Multiple imputation of timing of mother-to-child transmission of HIV
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- Abstract:
In this paper, we present a model for imputing timing of mother-to- child transmission (MTCT) of HIV. The method re ects the three modes of MTCT of HIV: in utero, during delivery and via breastfeeding and can accomodate shapes for the baseline hazard that vary between infants. Ad- ditionally, it allows that the majority of infants do not experience MTCT of HIV. Final analyses from the imputed data sets are combined in a mul- tiple imputation framework. The methods is illustrated on a large trial designed to assess the use of antibiotics in preventing MTCT of HIV and is validated using simulations. Additionally, we explore appropriate censoring techniques to account for weaning.
- Subject Area:
- Survival Analysis
- Suggested Citation:
- Elizabeth Brown and Ying Qing Chen,
"Multiple imputation of timing of mother-to-child transmission of HIV"
(February 25, 2008).
UW Biostatistics Working Paper Series.
Working Paper 324.
http://www.bepress.com/uwbiostat/paper324