Abstract

We address the problem of detection and correction of spatial flaws in oligonucleotide microarrays. We present two similar procedures, of which one is intended solely for use with replicates and the other has wider applicability. By constructing a set of replicates, with one realistically flawed, we are able to examine the extent to which our procedures are capable of repairing the flaw. We find that, for this purpose, our procedures are superior to the existing `Harshlight' procedure.

Submitted: May 14, 2008 · Accepted: September 4, 2008 · Published: October 17, 2008

Recommended Citation

Arteaga-Salas, Jose Manuel; Harrison, Andrew P.; and Upton, Graham J. G. (2008) "Reducing Spatial Flaws in Oligonucleotide Arrays by Using Neighborhood Information," Statistical Applications in Genetics and Molecular Biology: Vol. 7 : Iss. 1, Article 29.
DOI: 10.2202/1544-6115.1383
Available at: http://www.bepress.com/sagmb/vol7/iss1/art29

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