Ameliorative Role of Vitamin E on Adverse Impact of Azadirachta indica in Reproductive Indices of Male Rats

Yinusa Raji, University of Ibadan Nigeria
Shakiru Ademola Salami, University of Ibadan Nigeria
Rahmat Adetutu Adisa, University of Ibadan Nigeria

Abstract

This study was undertaken to determine the role of vitamin E on reproductive activity of <em>Azadirachta indica</em> extract in rats. Forty adult male albino rats were divided into 5 equal groups. The control group received distilled water while the other groups were treated with <em>Azadirachta indica</em> (150mg/kg bwt) extract alone, vitamin E (100mg/kg bwt) alone, combined <em>Azadirachta indica</em> (150mg/kg bwt) and vitamin E (100mg/kg bwt), and combined <em>Azadirachta indica</em> (150 mg/kg bwt) and vitamin E (150 mg/kg bwt). Group administered <em>Azadirachta indica</em> alone showed significant (p<0.05) decrease in sperm count, viability and motility. Co-administration of <em>A. indica</em> with vitamin E caused an increase in values of these parameters. Serum testosterone concentration decreased significantly (p<0.05) in <em>A. indica</em> only treated group with concomitant increase in groups co-administered with vitamin E. Lipid peroxidation showed significant decrease (p<0.05) in all treated groups with group co-administered with vitamin E showing enhanced modulatory effect than group administered with <em>Azadirachta indica</em> extract alone. Superoxide dismutase (SOD) activity was also significantly (p<0.05) enhanced in all treated groups; the groups treated with vitamin E showed higher activity. The results suggest possible ameliorative effect of vitamin E on adverse impact of <em>Azadirachta indica</em> in reproductive activity of male rats.

Submitted: December 24, 2008 · Accepted: March 9, 2009 · Published: April 16, 2009

Recommended Citation

Raji, Yinusa; Salami, Shakiru Ademola; and Adisa, Rahmat Adetutu (2009) "Ameliorative Role of Vitamin E on Adverse Impact of Azadirachta indica in Reproductive Indices of Male Rats," Journal of Complementary and Integrative Medicine: Vol. 6 : Iss. 1, Article 10.
DOI: 10.2202/1553-3840.1224
Available at: http://www.bepress.com/jcim/vol6/iss1/10

 
 
 
 

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