Abstract

Inhibitors of an angiotensin I-converting enzyme were produced from α-zein in a batch reactor under subcritical and supercritical water conditions. Inhibitors produced under supercritical conditions in a flow reactor assembly were more sensitive. In a flow reactor system 5 mg of inhibitors were produced from 1 micromole of α-zein. The hydrolysis products of α-zein obtained in the flow reactor had a higher ACE inhibitory activity of 78% compared to 69% obtained using the batch reactor. An angiotensin I-converting enzyme [EC 3.4. 1 5. l] (ACE) is used to catalyze the production of vasoconstrictor angiotensin II and for the inactivation of the vasodilator bradykinin.

Recommended Citation

Hatakeda, Kiyotaka; Maruyama, Susumu; Suzuki, Akira; and Arai, Kunio (2008) "Conversion of α-Zein to an Angiotensin I-Converting Enzyme Inhibitor under the Supercritical Water Condition," International Journal of Chemical Reactor Engineering: Vol. 6: A65.
Available at: http://www.bepress.com/ijcre/vol6/A65