On the Accelerated Failure Time Model for Current Status and Interval Censored Data
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Abstract:
This paper introduces a novel approach to making inference about the regression parameters in the accelerated failure time (AFT) model for current status and interval censored data. The estimator is constructed by inverting a Wald type test for testing a null proportional hazards model. A numerically efficient Markov chain Monte Carlo (MCMC) based resampling method is proposed to simultaneously obtain the point estimator and a consistent estimator of its variance-covariance matrix. We illustrate our approach with interval censored data sets from two clinical studies. Extensive numerical studies are conducted to evaluate the finite sample performance of the new estimators.
Subject Area:
Computation, Survival Analysis
Suggested Citation:
Lu Tian and Tianxi Cai, "On the Accelerated Failure Time Model for Current Status and Interval Censored Data" (September 2004). Harvard University Biostatistics Working Paper Series. Working Paper 14.
http://www.bepress.com/harvardbiostat/paper14